Are polynucleotide results instant?

Polynucleotides are gaining popularity in aesthetic medicine due to their impressive regenerative and rejuvenating properties. However, one of the most common questions patients have is whether the results of polynucleotide treatments are instant. This article delves into the timeline of results for polynucleotide treatments.

What Are Polynucleotides?

Polynucleotides are long chains of nucleotides, which form the basic building blocks of DNA and RNA. In aesthetic treatments, polynucleotides are used for their ability to stimulate skin regeneration and repair. When injected into the skin, they promote collagen and elastin production, improve hydration, and support tissue repair, leading to healthier, more youthful-looking skin.

The Mechanism of Polynucleotides

Polynucleotides work by providing a structural framework that supports cellular regeneration. They attract water molecules, which helps to improve skin hydration and provide a plumping effect. This mechanism helps reduce fine lines and wrinkles and improve overall skin texture and tone. Unlike treatments that offer immediate visible changes, polynucleotides work gradually to enhance the skin’s natural repair processes.

Understanding the Timeline of Results

Immediate Effects

Immediately after the polynucleotide injection, you may notice some initial effects due to the hydration and plumping of the skin. These immediate changes are often subtle and primarily due to the physical presence of the injected solution rather than the biological activity of the polynucleotides.

Short-term Changes

In the first few days following the treatment, you might experience some mild redness, swelling, or bruising at the injection sites. These effects are temporary and typically subside within a few hours to a couple of days. The initial improvement in skin texture and hydration may become more noticeable during this period, but these are still early effects.

Gradual Improvements

Polynucleotide treatments are designed to work over time by stimulating the skin’s natural regenerative processes. Significant improvements usually become noticeable within a few weeks. During this time, the polynucleotides promote collagen and elastin production, leading to better skin elasticity and firmness. The skin’s overall appearance continues to improve as these structural proteins rebuild and strengthen the skin matrix.

Long-term Results

The full results of polynucleotide treatments typically manifest after two to three months. By this time, the skin should appear significantly rejuvenated, with reduced fine lines and wrinkles, improved texture, and enhanced hydration. The long-lasting benefits of polynucleotides can be maintained for six to twelve months, depending on individual factors and the specific area treated.

Benefits of Gradual Results

The gradual nature of polynucleotide results offers several advantages. Firstly, it ensures a more natural-looking improvement, avoiding the sudden and sometimes artificial appearance associated with more immediate treatments. Secondly, the progressive enhancement allows the skin to adapt and respond to the treatment over time, resulting in more sustainable and long-lasting benefits.

Choosing the Right Clinic

When considering polynucleotide treatments, selecting a reputable clinic with experienced practitioners is essential. A thorough consultation should be conducted to assess your skin condition and discuss your aesthetic goals. The practitioner should provide detailed information about the treatment process, potential side effects, and the expected timeline of results to ensure a clear understanding and realistic expectations.


While polynucleotide results are not instant, their gradual and natural improvements make them an excellent choice for those seeking long-term skin rejuvenation. The progressive enhancement in skin texture, tone, and elasticity offers a sustainable and natural-looking outcome. If you are based in Clapham or South London and are interested in exploring polynucleotide treatments, our clinic offers expert guidance and personalized care to help you achieve your aesthetic goals safely and effectively.

Contact us today at our BTX London clinic in Balham for a personalised consultation. We’re more than just a Botox clinic—we’re your partners in your aesthetic journey in Clapham.

Feel free to book Botox treatments at our clinic in Balham with Dr. Raman here.

Our clinic has another article about the long-term safety of polynucleotides.

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