How do polynucleotides differ from other skin boosters like Profhilo?

In the ever-evolving world of aesthetic medicine, numerous skin boosters are available to rejuvenate and enhance the skin’s appearance. Among these, polynucleotides and Profhilo have gained considerable attention for their unique benefits. Understanding the differences between polynucleotides and other skin boosters like Profhilo is essential for making an informed decision about which treatment is best suited for your needs. This article explores the distinctions between these treatments, focusing on their mechanisms, uses, and benefits.

What Are Polynucleotides?

Polynucleotides are long chains of nucleotides, which are the building blocks of DNA and RNA. In aesthetic treatments, polynucleotides are used for their regenerative properties, promoting skin repair and rejuvenation. They work by enhancing the skin’s natural healing processes, leading to improved texture, hydration, and overall skin health.

Mechanism of Action

Polynucleotides work by providing a structural framework for cellular regeneration. When injected into the skin, they attract water molecules, which improves skin hydration and provides a plumping effect. Additionally, polynucleotides stimulate collagen and elastin production, leading to firmer and more youthful-looking skin.

What is Profhilo?

Profhilo is another popular skin booster that is widely used in aesthetic medicine. It is primarily composed of hyaluronic acid, a substance naturally found in the skin that plays a crucial role in maintaining hydration and elasticity. Profhilo is designed to improve skin texture, hydration, and overall radiance.

Mechanism of Action

Profhilo works by delivering a high concentration of hyaluronic acid into the skin. This hyaluronic acid spreads evenly throughout the skin, providing intense hydration and stimulating the production of collagen and elastin. The result is improved skin firmness, elasticity, and a radiant complexion.

Key Differences Between Polynucleotides and Profhilo


The most significant difference between polynucleotides and Profhilo lies in their composition. Polynucleotides are made up of nucleotide chains, while Profhilo is composed of pure hyaluronic acid. This fundamental difference in ingredients leads to varying mechanisms of action and benefits.

Mechanism of Action

While both treatments aim to rejuvenate the skin, they do so through different mechanisms. Polynucleotides work by creating a supportive framework for cell regeneration and enhancing the skin’s natural repair processes. In contrast, Profhilo focuses on delivering intense hydration and stimulating collagen and elastin production through the action of hyaluronic acid.

Treatment Goals

Polynucleotides and Profhilo both target skin rejuvenation but with slightly different goals. Polynucleotides are particularly effective for improving overall skin health, texture, and tone by promoting natural repair mechanisms. They are also used for treating scars and other skin imperfections. Profhilo, on the other hand, is primarily used for its hydrating effects and for achieving a glowing, radiant complexion.

Duration of Results

The duration of results can vary between the two treatments. Polynucleotide treatments typically show gradual improvements over several weeks, with effects lasting six to twelve months, depending on individual factors. Profhilo, known for its rapid hydrating effect, often provides noticeable improvements within a few weeks, with results lasting around six months.

Which Treatment is Right for You?

Choosing between polynucleotides and Profhilo depends on your specific skin concerns and aesthetic goals. If you are looking for comprehensive skin rejuvenation that includes improved texture, reduced pigmentation, and overall skin repair, polynucleotides may be the better option. On the other hand, if your primary concern is achieving deep hydration and a radiant glow, Profhilo might be more suitable.


Understanding the differences between polynucleotides and Profhilo can help you make an informed decision about your skincare routine. Both treatments offer unique benefits and can be tailored to meet your specific needs. If you are based in Clapham or South London and are interested in exploring these treatments, contact our clinic for expert advice and personalized care. Our goal is to help you achieve healthier, more youthful-looking skin with the treatment that is right for you.

Contact us today at our BTX London clinic in Balham for a personalised consultation. We’re more than just a Botox clinic—we’re your partners in your aesthetic journey in Clapham.

Feel free to book Botox treatments at our clinic in Balham with Dr. Raman here.

Our clinic has another article about whether polynucleotides results are instant.

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