How long does a polynucleotides treatment last?

Polynucleotide treatments have become a popular choice for individuals seeking skin rejuvenation and repair due to their regenerative properties. Understanding the duration of a polynucleotide treatment’s effects is crucial for those considering this option. This article explores how long the benefits of polynucleotide treatments last, with a focus on their application and impact.

What Are Polynucleotides?

Polynucleotides are long chains of nucleotides, the building blocks of DNA and RNA. In aesthetic medicine, polynucleotides are used for their ability to stimulate skin regeneration and repair. When injected into the skin, they promote collagen and elastin production, improve hydration, and support tissue repair, leading to healthier, more youthful-looking skin.

Mechanism of Action

Polynucleotides work by providing a structural framework that supports cellular regeneration. They attract water molecules, which improves skin hydration and provides a plumping effect. Additionally, polynucleotides stimulate collagen and elastin production, which enhances skin elasticity and firmness. This multi-faceted approach to skin rejuvenation helps to address various signs of aging and skin damage.

Duration of Polynucleotide Treatment Effects

Immediate Effects

Immediately after a polynucleotide injection, you may notice some initial effects due to the hydration and plumping of the skin. These immediate changes are often subtle and primarily due to the physical presence of the injected solution rather than the biological activity of the polynucleotides.

Short-term Results

In the first few days following the treatment, you might experience some mild redness, swelling, or bruising at the injection sites. These effects are temporary and typically subside within a few hours to a couple of days. During this period, initial improvements in skin texture and hydration may become more noticeable.

Gradual Improvements

Significant improvements from polynucleotide treatments usually become noticeable within a few weeks. This is when the polynucleotides begin to stimulate collagen and elastin production, leading to better skin elasticity and firmness. The skin’s overall appearance continues to improve as these structural proteins rebuild and strengthen the skin matrix.

Long-term Results

The full benefits of polynucleotide treatments typically manifest after two to three months. By this time, the skin should appear significantly rejuvenated, with reduced fine lines and wrinkles, improved texture, and enhanced hydration. The long-lasting effects of polynucleotides can be maintained for six to twelve months, depending on individual factors and the specific area treated.

Factors Influencing the Duration of Results

Several factors can influence how long the results of a polynucleotide treatment last. These include:

  1. Skin Type and Condition: The initial condition of your skin and its ability to respond to treatment can affect the duration of the results.
  2. Age: Younger skin may respond more quickly and maintain results longer compared to older skin.
  3. Lifestyle: Factors such as diet, hydration, sun exposure, and skincare routines can impact the longevity of the treatment’s effects.
  4. Treatment Area: Different areas of the skin may respond differently to treatment, influencing how long the results last.

Maintenance Treatments

To maintain the benefits of polynucleotide treatments, periodic maintenance sessions are recommended. These follow-up treatments help to sustain the improvements in skin texture, hydration, and elasticity. Your practitioner will advise on the optimal frequency for maintenance sessions based on your individual needs and the specific characteristics of your skin.

Choosing the Right Clinic

When considering polynucleotide treatments, it is essential to choose a reputable clinic with experienced practitioners. A thorough consultation should be conducted to assess your skin condition and discuss your aesthetic goals. The practitioner should provide detailed information about the treatment process, potential side effects, and aftercare instructions to ensure a safe and satisfying experience.


The effects of polynucleotide treatments are long-lasting, with significant improvements in skin texture, tone, and hydration typically maintained for six to twelve months. While immediate results may be subtle, the full benefits of the treatment become evident over time, offering natural and sustainable skin rejuvenation. If you are based in Clapham or South London and are interested in exploring polynucleotide treatments, our clinic offers expert guidance and personalized care to help you achieve your aesthetic goals safely and effectively.

Contact us today at our BTX London clinic in Balham for a personalised consultation. We’re more than just a Botox clinic—we’re your partners in your aesthetic journey in Clapham.

Feel free to book Botox treatments at our clinic in Balham with Dr. Raman here.

Our clinic has another article about the differences between Profhilo and Polynucleotides.

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