Long-term safety of polynucleotides

Polynucleotides have gained significant attention in the world of aesthetic medicine due to their promising benefits for skin rejuvenation and repair. However, like any treatment, understanding the long-term safety of polynucleotides is crucial for those considering this option. This article delves into the long-term safety of polynucleotides, with a focus on their application and impact for individuals.

What Are Polynucleotides?

Polynucleotides are long chains of nucleotides, which are the fundamental building blocks of DNA and RNA. In the context of aesthetic treatments, polynucleotides are used for their regenerative properties. When injected into the skin, they promote collagen and elastin production, enhance hydration, and support tissue repair, leading to healthier, more youthful-looking skin.

Mechanism of Action

Polynucleotides work by providing a structural framework that supports cellular regeneration. They attract water molecules, improving skin hydration and providing a plumping effect. This mechanism helps to reduce fine lines and wrinkles and improve overall skin texture and tone. The regenerative properties of polynucleotides also make them effective for treating scars and other skin imperfections.

Evaluating Long-term Safety

The long-term safety of polynucleotides has been a topic of extensive research. Studies have shown that polynucleotides are biocompatible, meaning they are well-tolerated by the body without causing adverse reactions. Here are some key factors that contribute to their long-term safety:


One of the primary reasons polynucleotides are considered safe is their biodegradability. Polynucleotides are naturally broken down and absorbed by the body over time, reducing the risk of long-term complications. This natural degradation process ensures that the body does not accumulate foreign substances, which is crucial for long-term safety.

Minimal Side Effects

Clinical studies have indicated that polynucleotide treatments have minimal side effects. Common side effects are typically mild and temporary, including redness, swelling, and minor bruising at the injection sites. These effects usually subside within a few hours to a couple of days. The low incidence of severe side effects makes polynucleotides a safe option for long-term use.

Natural Origin

Polynucleotides are derived from natural sources, often extracted from salmon DNA, which closely resembles human DNA. This similarity enhances their compatibility with human tissues, reducing the risk of allergic reactions and other adverse effects. The use of natural, biocompatible materials is a significant factor in the long-term safety of polynucleotides.

Ongoing Research

The safety and efficacy of polynucleotides are continually being studied. Ongoing research aims to explore new applications and improve existing treatments, ensuring that polynucleotide therapies remain safe and effective for long-term use. Regulatory bodies closely monitor these treatments to ensure they meet stringent safety standards.

Clinical Applications and Safety Profile

In clinical practice, polynucleotide treatments have demonstrated a strong safety profile. They are used not only for cosmetic purposes but also in medical applications, such as wound healing and tissue repair. The versatility and safety of polynucleotides have made them a valuable tool in both aesthetic and medical fields.

Choosing the Right Clinic

When considering polynucleotide treatments, it is essential to choose a reputable clinic with experienced practitioners. A thorough consultation should be conducted to assess your skin condition and discuss your aesthetic goals. The practitioner should provide detailed information about the treatment process, potential side effects, and aftercare instructions to ensure a safe and satisfying experience.


The long-term safety of polynucleotides is well-supported by clinical research and practical experience. Their biocompatibility, minimal side effects, and natural origin contribute to their safety profile, making them a viable option for those seeking skin rejuvenation and repair. If you are based in Clapham or South London and are interested in exploring polynucleotide treatments, our clinic offers expert guidance and personalized care to help you achieve your aesthetic goals safely.

Contact us today at our BTX London clinic in Balham for a personalised consultation. We’re more than just a Botox clinic—we’re your partners in your aesthetic journey in Clapham.

Feel free to book Botox treatments at our clinic in Balham with Dr. Raman here.

Our clinic has another article about the difference between Botox and Polynucleotides.

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