Polynucleotides: behind the hype

Polynucleotides have garnered significant attention in the world of aesthetic medicine, praised for their regenerative properties and effectiveness in skin rejuvenation. As with any popular treatment, it’s essential to look beyond the hype and understand the science, benefits, and realistic expectations associated with polynucleotides.

The Science Behind Polynucleotides

Molecular Structure and Function

Polynucleotides consist of repeated units of nucleotides, each composed of three parts: a nitrogenous base, a sugar molecule, and a phosphate group. These nucleotides link together to form long chains, which can be incorporated into treatments to support cellular functions and promote tissue repair.

Mechanism of Action

Polynucleotides work by providing a structural framework that supports cellular regeneration. They attract water molecules, improving skin hydration and providing a plumping effect. Additionally, polynucleotides stimulate collagen and elastin production, essential proteins for maintaining skin firmness and elasticity. This multi-faceted approach helps to address various signs of aging, including wrinkles and fine lines.

Benefits of Polynucleotide Treatments

Skin Rejuvenation

One of the primary benefits of polynucleotide treatments is their ability to rejuvenate the skin. By enhancing the skin’s natural repair processes, these treatments can improve overall skin texture, tone, and elasticity. This makes polynucleotides particularly beneficial for individuals looking to reduce signs of aging and achieve a more youthful appearance.

Long-Lasting Results

Polynucleotide treatments are known for their long-lasting effects. While the initial improvements may become noticeable within a few weeks, the full benefits typically manifest after two to three months. The results can be maintained for six to twelve months, depending on individual factors and the specific area treated.

Minimally Invasive

Unlike surgical procedures, polynucleotide treatments are minimally invasive. They involve a series of injections, making them a convenient option for individuals with busy lifestyles. The treatment has minimal downtime, allowing patients to resume their daily activities shortly after the procedure.

Why the Hype?

Effective and Natural-Looking Results

The hype around polynucleotides is largely due to their effectiveness in delivering natural-looking results. Unlike treatments that provide immediate but temporary effects, polynucleotides work gradually to improve the skin’s condition from within. This leads to more subtle and natural enhancements, which are highly valued by patients.


Polynucleotides are versatile and can be used to treat various skin concerns, from wrinkles and fine lines to scars and overall skin rejuvenation. This versatility makes them an attractive option for a wide range of patients seeking different aesthetic improvements.

Managing Expectations

While polynucleotides offer numerous benefits, it’s essential to manage expectations. Results vary from person to person, and factors such as age, skin type, and lifestyle can influence the outcome. During a consultation, your practitioner will discuss realistic expectations and develop a treatment plan tailored to your specific needs.

Choosing the Right Clinic

When considering polynucleotide treatments, it is essential to choose a reputable clinic with experienced practitioners. A thorough consultation should be conducted to assess your skin condition and discuss your aesthetic goals. The practitioner should provide detailed information about the treatment process, potential side effects, and aftercare instructions to ensure a safe and satisfying experience. Our Clapham clinic offers expert guidance and personalized care to help you achieve your aesthetic goals safely and effectively.

Contact us today at our BTX London clinic in Balham for a personalised consultation. We’re more than just a Botox clinic—we’re your partners in your aesthetic journey in Clapham.

Feel free to book Botox treatments at our clinic in Balham with Dr. Raman here.

Our clinic has another article about why polynucleotides may not be suitable for vegans.

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