Should I do a polynucleotides treatment if I’ve already been treated with botox in the past for the area? How soon after a botox treatment can I try polynucleotides?

Polynucleotide treatments and Botox are both popular options in aesthetic medicine, each offering unique benefits for skin rejuvenation and anti-aging. If you’ve already been treated with Botox in the past, you might be wondering whether you can still benefit from polynucleotide treatments and how soon after Botox you can try them. 

Understanding Polynucleotide Treatments and Botox

Polynucleotide Treatments

Polynucleotides are long chains of nucleotides, the building blocks of DNA and RNA, used in aesthetic treatments to enhance skin regeneration, improve hydration, and stimulate collagen and elastin production. These treatments result in healthier, more youthful-looking skin with improved texture and elasticity.


Botox, or botulinum toxin, is a neurotoxin that temporarily paralyzes muscles to reduce the appearance of wrinkles and fine lines. It is commonly used to treat dynamic wrinkles, such as crow’s feet, forehead lines, and frown lines.

Combining Polynucleotide Treatments and Botox

Compatibility of Treatments

Polynucleotide treatments and Botox are compatible and can be used in conjunction to achieve comprehensive skin rejuvenation. While Botox targets muscle activity to smooth out dynamic wrinkles, polynucleotides work on a cellular level to improve skin health, texture, and hydration. Together, these treatments can provide both immediate and long-term anti-aging benefits.

Benefits of Combining Treatments

  1. Enhanced Skin Health: Polynucleotides promote cellular regeneration and collagen production, enhancing overall skin quality. This complements the wrinkle-smoothing effects of Botox.
  2. Holistic Rejuvenation: Using both treatments can address different aspects of aging, providing a more holistic approach to skin rejuvenation.
  3. Sustained Results: Combining treatments can help maintain youthful skin for longer periods, as polynucleotides support ongoing skin health while Botox addresses specific wrinkle concerns.

Timing Between Treatments

Post-Botox Considerations

If you’ve recently had Botox, it’s important to allow some time before undergoing a polynucleotide treatment. This ensures that each treatment can be effective and that your skin has time to respond to the Botox.

  1. Wait at Least Two Weeks: Generally, it’s recommended to wait at least two weeks after a Botox treatment before having a polynucleotide treatment. This waiting period allows the Botox to fully settle and take effect, ensuring that your muscles have relaxed and any initial swelling or bruising has subsided.
  2. Consult Your Practitioner: The exact timing can vary based on individual factors such as the treated area, the amount of Botox used, and your skin’s response. It’s essential to consult with your practitioner to determine the appropriate timing for your treatments.

Choosing the Right Clinic

When considering polynucleotide treatments, especially if you have previously had Botox, selecting a reputable clinic with experienced practitioners is crucial. A thorough consultation should be conducted to assess your skin condition, discuss your aesthetic goals, and develop a treatment plan tailored to your needs. Dr. Raman will provide detailed information about the treatment process, potential side effects, and aftercare instructions to ensure a safe and satisfying experience.


Polynucleotide treatments and Botox can be effectively combined to achieve comprehensive skin rejuvenation. If you have already been treated with Botox, you can still benefit from polynucleotide treatments by allowing an appropriate waiting period. For those in Clapham and South London, our clinic offers expert guidance and personalized care to help you achieve your aesthetic goals safely and effectively. Understanding the compatibility and timing of these treatments can enhance your skincare routine and provide long-lasting results.

Contact us today at our BTX London clinic in Balham for a personalised consultation. We’re more than just a Botox clinic—we’re your partners in your aesthetic journey in Clapham.

Feel free to book Botox treatments at our clinic in Balham with Dr. Raman here.

Our clinic has another article about whether there are benefits to getting a polynucleotides treatment early.

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