The science behind polynucleotides

Polynucleotides have gained significant attention in aesthetic medicine due to their remarkable regenerative properties. Understanding the science behind polynucleotides can help individuals appreciate how these treatments work to rejuvenate and repair the skin. 

What Are Polynucleotides?

Polynucleotides are long chains of nucleotides, the basic building blocks of DNA and RNA. These molecules play a crucial role in various biological processes, including cell division, repair, and regeneration. In aesthetic treatments, polynucleotides are used for their ability to enhance the skin’s natural repair mechanisms and promote rejuvenation.

Molecular Structure and Function

Composition of Polynucleotides

Polynucleotides consist of repeated units of nucleotides, each composed of three parts: a nitrogenous base, a sugar molecule, and a phosphate group. These nucleotides link together to form long chains, which can be incorporated into treatments to support cellular functions and promote tissue repair.

Role in Cellular Regeneration

Polynucleotides support cellular regeneration by providing a structural framework that facilitates cell division and repair. When injected into the skin, they act as scaffolds that help organize and stabilize the extracellular matrix. This process enhances the skin’s ability to produce collagen and elastin, crucial proteins for maintaining skin firmness and elasticity.

Mechanism of Action

Hydration and Plumping Effect

One of the immediate effects of polynucleotide injections is the improvement of skin hydration. Polynucleotides attract and bind water molecules, leading to a plumping effect that enhances skin volume and reduces the appearance of fine lines and wrinkles. This hydrating property is particularly beneficial for individuals with dry or aging skin.

Stimulation of Collagen and Elastin Production

Polynucleotides play a pivotal role in stimulating the production of collagen and elastin. These proteins are essential for maintaining the skin’s structural integrity and elasticity. By promoting their synthesis, polynucleotides help to firm and tighten the skin, resulting in a more youthful appearance.

Clinical Benefits

Skin Rejuvenation

Polynucleotide treatments are highly effective for skin rejuvenation. By enhancing the skin’s natural repair processes, these treatments can improve overall skin texture, tone, and elasticity. They are particularly beneficial for individuals with signs of aging, such as wrinkles, fine lines, and sagging skin.

Scar Reduction

In addition to their anti-aging benefits, polynucleotides can also be used to treat scars. The regenerative properties of polynucleotides help to remodel scar tissue, making it less noticeable and improving the overall appearance of the skin.

Applications in Aesthetic Medicine

Treatment Protocols

Polynucleotide treatments are typically administered through a series of injections. The exact protocol may vary depending on the individual’s skin condition and aesthetic goals. A thorough consultation with a qualified practitioner is essential to determine the most appropriate treatment plan.

Suitability for Different Skin Types

Polynucleotide treatments are suitable for a wide range of skin types and conditions. Whether you have mature skin showing signs of aging or are looking to improve the appearance of scars, polynucleotides offer a versatile solution. The treatments are also suitable for individuals with sensitive skin, as they are generally well-tolerated and have minimal side effects.

Choosing the Right Clinic

When considering polynucleotide treatments, it is essential to choose a reputable clinic with experienced practitioners. A thorough consultation should be conducted to assess your skin condition and discuss your aesthetic goals. The practitioner should provide detailed information about the treatment process, potential side effects, and aftercare instructions to ensure a safe and satisfying experience.


The science behind polynucleotides underscores their effectiveness in promoting skin regeneration and rejuvenation. By understanding their molecular structure and mechanism of action, individuals can appreciate how these treatments work to improve skin texture, tone, and elasticity. If you are based in Clapham or South London and are interested in exploring polynucleotide treatments, our clinic offers expert guidance and personalized care to help you achieve your aesthetic goals safely and effectively.

Contact us today at our BTX London clinic in Balham for a personalised consultation. We’re more than just a Botox clinic—we’re your partners in your aesthetic journey in Clapham.

Feel free to book Botox treatments at our clinic in Balham with Dr. Raman here.

Our clinic has another article about whether polynucleotides treatments work if you already have wrinkles.

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