What is the difference between botox and polynucleotides?

In the realm of aesthetic treatments, Botox and polynucleotides are two popular options that offer distinct benefits for skin rejuvenation. Understanding the differences between these treatments can help you make an informed decision about which one is best suited for your needs. Here, we explore the key differences between Botox and polynucleotides, focusing on their mechanisms, uses, and benefits.

What is Botox?

Botox, short for Botulinum Toxin, is a neurotoxic protein produced by the bacterium Clostridium botulinum. It is widely used in cosmetic procedures to reduce the appearance of wrinkles and fine lines. Botox works by temporarily paralyzing the muscles it is injected into, preventing them from contracting and forming wrinkles.

Mechanism of Action

When Botox is injected into specific muscles, it blocks the nerve signals that cause these muscles to contract. This relaxation of the muscles smooths out the overlying skin, reducing the appearance of dynamic wrinkles, such as crow’s feet, frown lines, and forehead lines.


Botox is primarily used for cosmetic purposes. It is highly effective at reducing facial wrinkles and fine lines, making it a popular choice for those looking to achieve a more youthful appearance. Additionally, Botox is used in medical treatments to control excessive sweating, also known as hyperhidrosis, treat chronic migraines, and manage muscle spasms and other neuromuscular conditions.


The benefits of Botox include a quick and relatively painless procedure that provides immediate results, which improve over a few days. The effects typically last for three to six months, making it a convenient option for maintaining a youthful appearance. With minimal downtime and quick recovery, Botox is an attractive choice for many individuals seeking cosmetic enhancements.

What are Polynucleotides?

Polynucleotides are long chains of nucleotides, which are the building blocks of DNA and RNA. In aesthetic treatments, polynucleotides are used for their regenerative properties, promoting skin repair and rejuvenation. They work differently from Botox by enhancing the skin’s natural healing processes.

Mechanism of Action

Polynucleotides work by providing a structural framework for cellular regeneration. When injected into the skin, they promote collagen and elastin production, improve hydration, and support tissue repair. This leads to healthier, more youthful-looking skin.


Polynucleotides are highly effective for skin rejuvenation. They improve skin texture, reduce pigmentation, and enhance overall skin tone. Polynucleotides are also used to treat scars and stretch marks, providing a non-invasive solution for various skin imperfections. For individuals with dry or aging skin, polynucleotides offer significant hydration benefits, resulting in a more plump and youthful appearance.


The benefits of polynucleotides include long-lasting skin rejuvenation effects that improve skin texture and elasticity. They enhance skin hydration and volume, making the skin look more youthful and vibrant. The treatment is non-invasive with minimal side effects, making it a safe and effective option for many individuals.

Key Differences Between Botox and Polynucleotides

The mode of action of Botox and polynucleotides differs significantly. Botox works by temporarily paralyzing muscles to reduce wrinkles, while polynucleotides stimulate skin regeneration and repair by enhancing collagen and elastin production. This difference in mechanism means that Botox is primarily used to target dynamic wrinkles caused by muscle movements, whereas polynucleotides focus on overall skin rejuvenation, improving skin texture, tone, and hydration.

The duration of effects also varies between the two treatments. Botox results last between three to six months, making it necessary to schedule regular treatments to maintain the desired appearance. On the other hand, polynucleotides offer effects that can last from six to twelve months, depending on individual factors and the area treated. This longer duration of effect can be more convenient for those looking for longer-lasting skin improvements.

The procedure and recovery time for both treatments also differ. Botox involves a quick procedure with minimal downtime and immediate results. Polynucleotide treatments involve a series of injections with gradual improvements that become noticeable over weeks to months. Despite the slower onset of results, the long-lasting benefits of polynucleotides make them a popular choice for comprehensive skin rejuvenation.

Which Treatment is Right for You?

Choosing between Botox and polynucleotides depends on your specific aesthetic goals and skin concerns. If you are looking to reduce dynamic wrinkles and enjoy quick results, Botox might be the right choice for you. On the other hand, if you seek overall skin rejuvenation with long-lasting benefits, polynucleotides may be more suitable.

Our Clapham clinic offers both Botox and polynucleotide treatments. Our experienced practitioners can help you determine the best treatment plan based on your individual needs and desired outcomes. Book a consultation today to explore the transformative potential of these advanced aesthetic treatments.


Understanding the differences between Botox and polynucleotides can help you make an informed decision about your skincare routine. Both treatments offer unique benefits and can be tailored to meet your specific needs. If you are based in Clapham or South London and are interested in learning more about these treatments, contact our clinic for expert advice and personalized care.

Contact us today at our BTX London clinic in Balham for a personalised consultation. We’re more than just a Botox clinic—we’re your partners in your aesthetic journey in Clapham.

Feel free to book Botox treatments at our clinic in Balham with Dr. Raman here.

Our clinic has another article about how polynucleotides work.

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